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Member
Posts: 2
Registered: ‎04-16-2015
0

calcium gluconate iv bags batch prep

We are trying to convert from purchasing bags of 4 gram in 250ml saline with room temp storage and stocked in critical care ADS machines to batching on site in pharmacy clean room. Cannot find stability beyond 24 hours which would make this process not feasible. Does anyone have any better BUD information?
Expert
Posts: 1,167
Registered: ‎02-23-2010

Re: calcium gluconate iv bags batch prep

rxpah,

 

Calcium Gluconate is an inorganic salt and doesn't "degrade" like other molecules.  It becomes dissociated in solution and is stable for years. The problem is that no one has studied electrolyte stability over time.  The issue is going to be sterility over time, especially since you want to store these drugs at room temperature. 

Eric S. Kastango, MBA, RPh, FASHP

It's all about the patient.
Occasional Advisor
Posts: 9
Registered: ‎05-26-2015
0

Re: calcium gluconate iv bags batch prep

We had this same question with KPhos.  We made room in our refrigerator in our critical care areas(controlled by ADS) so that we could take advantage of the longer BUD.

Member
Posts: 2
Registered: ‎04-16-2015
0

Re: calcium gluconate iv bags batch prep

Yes, I've considered placing a second refrigerator(ADS) controlled for this purpose but was hoping could get some data to support room temperature since the ADS towers have the room for the volume needed (30-60 bags/day)

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Advisor
Posts: 17
Registered: ‎02-27-2016
0

Re: calcium gluconate iv bags batch prep

Consider:

Calcium Gluconate 1 gram vial and 50 mL or 100 mL NS B. Braun PAB bag attached via addEASE

BUD Room Temp = 70 days

http://video.bbraunusa.com/vsc_3868_1030_1_vid_882874/addease-instructional-video.html

 

http://www.usp.org/sites/default/files/usp_pdf/EN/USPNF/usp-gc-797-proposed-revisions-sep-2015.pdf (pages 85-86)