I have several question about this topic. First what is everyone else doing? We are having a hard time getting anesthesia to change to either vec or roc any help here would be great.
Second question is - Can we draw up the succ's into 100 mg syringes? If so what kind of BUD can we give them. I know out of the fridge now they get 14 days. do they get the same if drawin into 100 mg syringes. Can we draw them into syringe and place back into fridge for a longer BUD. Any help would be great!!!
I believe there would be chemical stability for pulling in syringes. You would have the following options 1) room temperature 30 hours or 2) refrigeration 9 days (Medium risk) or 3) you could use the full chemical stability data and culture them to use the BUD.
09-20-201011:22 AM - last edited on 09-20-201011:23 AM
I agree with Bryan's response. Chemical stability according to Trissel's Handbook of Injectable Drugs, 15th ed. states that succinylcholine is chemical stable for extended periods of time at both room temperature and refrigerated. Since you would be batching these syringes, following the medium-risk level CSP BUD would be the best route to take during the shortage. If you are going to perform sterility tests, it would be advisable to follow the requirements in USP Chapter <71>.
You can reply to this forum thread once you are able to review available information and formulate a proposed solution/course of action to your question. I’d be more than happy to comment if you are still unclear once you have done your due diligence in researching this issue.
