04-24-2017 08:41 AM
My facility is moving and is working on a new cleanroom layout. We have opted to build two negative pressure rooms. One will be for compounding and the other for the storage of HDs that require further manipulation prior to dispense and antineoplastics. The entry to the negative pressure storage are will be located on the "dirty" side of the line of demarcation in the ante area. We are wanting to include a pass-through between the two rooms. Are there any specific requirements for a pass through from negative to negative pressure? Thank you for your help!
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05-10-2017 10:57 AM
Erika - we have a negative pressure storage room for our HD (it is not ISO classified and is entered from the general pharmacy - it meets USP 800 requirements re: negative pressure and correct air changes/hr) with a pass thru into the negative pressure chemo buffer room. During design approval, our DOH/BOP required us to use a pass thru with a HEPA air shower between these 2 rooms because the storage room is not ISO classified.
05-10-2017 11:00 AM
You can purchase a HEPA filtered purged pass-through from AtmosTech. It will eliminate the concerns between the two spaces. It cannot be a refrigerator per USP 800.